TdfH selectively binds metal-loaded tetrameric calprotectin for zinc import.
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ABSTRACT:
SUBMITTER: Bera AK
PROVIDER: S-EPMC8803948 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Publications
TdfH selectively binds metal-loaded tetrameric calprotectin for zinc import.
Bera Aloke K AK Wu Runrun R Harrison Simone S Cornelissen Cynthia Nau CN Chazin Walter J WJ Noinaj Nicholas N
Communications biology 20220131 1
To combat nutritional immunity, N. gonorrhoeae has evolved systems to hijack zinc and other metals directly from host metal-binding proteins such as calprotectin (CP). Here, we report the 6.1 Å cryoEM structure of the gonococcal surface receptor TdfH in complex with a zinc-bound CP tetramer. We further show that TdfH can also interact with CP in the presence of copper and manganese, but not with cobalt. ...[more]
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