Oscillating the local milieu of polymersome interiors via single input-regulated bilayer crosslinking and permeability tuning.

ABSTRACT: The unique permselectivity of cellular membranes is of crucial importance to maintain intracellular homeostasis while adapting to microenvironmental changes. Although liposomes and polymersomes have been widely engineered to mimic microstructures and functions of cells, it still remains a considerable challenge to synergize the stability and permeability of artificial cells and to imitate local milieu fluctuations. Herein, we report concurrent crosslinking and permeabilizing of pH-responsive polymersomes containing Schiff base moieties within bilayer membranes via enzyme-catalyzed acid production. Notably, this synergistic crosslinking and permeabilizing strategy allows tuning of the mesh sizes of the crosslinked bilayers with subnanometer precision, showing discriminative permeability tow

SUBMITTER: Liu G 

PROVIDER: S-EPMC8803951 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature