Close genetic linkage between human and companion animal extraintestinal pathogenic Escherichia coli ST127.

ABSTRACT: Escherichia coli ST127, a recently emerged global pathogen noted for high virulence gene carriage, is a leading cause of urinary tract and blood stream infections. ST127 is frequently isolated from humans and companion animals; however, it is unclear if they are distinct or related populations of ST127. We performed a phylogenomic analysis of 299 E. coli ST127 of diverse epidemiological origin to characterize their population structure, genetic determinants of virulence, antimicrobial resistance, and repertoire of mobile genetic elements with a focus on plasmids. The core gene phylogeny was divided into 13 clusters, the largest of which (BAP4) contained the majority of human and companion animal origin isolates. This dominant cluster displayed genetic differences to the remai

SUBMITTER: Elankumaran P 

PROVIDER: S-EPMC8803956 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature