Chemotherapy-Induced Peripheral Neuropathy: Mechanisms and Therapeutic Avenues.

ABSTRACT: Chemotherapy-induced peripheral neuropathy (CIPN) is a serious and often persistent adverse consequence of certain chemotherapeutic agents. It is a major dose-limiting factor of many first-line chemotherapies, affecting 20-50% of patients at standard doses and nearly all patients at high doses. As cancer survivorship continues to increase with improvements in early diagnosis and treatment, more patients will experience CIPN despite completing cancer treatment, which interferes with recovery, leading to chronic pain and worsening quality of life. The National Cancer Institute has identified CIPN as a priority in translational research. To date, there are no FDA-approved drugs for preventing or treating CIPN, with emerging debate on mechanisms and promising new targets. This review highlight

SUBMITTER: Bae EH 

PROVIDER: S-EPMC8804039 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature