Cognitive Training in Parkinson's Disease Induces Local, Not Global, Changes in White Matter Microstructure.

ABSTRACT: Previous studies showed that cognitive training can improve cognitive performance in various neurodegenerative diseases but little is known about the effects of cognitive training on the brain. Here, we investigated the effects of our cognitive training paradigm, COGTIPS, on regional white matter microstructure and structural network topology. We previously showed that COGTIPS has small, positive effects on processing speed. A subsample of 79 PD patients (N = 40 cognitive training group, N = 39 active control group) underwent multi-shell diffusion-weighted imaging pre- and post-intervention. Our pre-registered analysis plan (osf.io/cht6g) entailed investigating white matter microstructural integrity (e.g., fractional anisotropy) in five tracts of interest, including the anterior thalamic r

SUBMITTER: Vriend C 

PROVIDER: S-EPMC8804148 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature