Metabolomic Alterations in the Tear Fluids of Patients With Superior Limbic Keratoconjunctivitis.

ABSTRACT:

Purpose

Superior limbic keratoconjunctivitis (SLK) is a bilateral, chronic inflammatory disease that recurs for up to several years; however, the fundamental processes involved in its pathogenic mechanisms remain unknown. We aimed to investigate the metabolomic alterations in the tear fluids of patients with superior limbic keratoconjunctivitis (SLK) compared with those of healthy volunteers (Ctrl group).

Methods

We performed a cross-sectional study involving 42 subjects. Tear fluid was taken from one eye of 24 SLK patients (40.13 ± 14.55 years, 83.33% female) and 18 healthy volunteers (Ctrl, 39.89 ± 9.2 years, 72.22% female) using Schirmer strips. After the liquid extraction of tear metabolites, samples were infused into the QE HFX Orbitrap mass spectrometer in both positiv

SUBMITTER: Zong Y 

PROVIDER: S-EPMC8804220 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature