A TLR/CD44 axis regulates T cell trafficking in experimental and human multiple sclerosis.

ABSTRACT: In the pathogenesis of autoimmune disorders, the modulation of leukocytes' trafficking plays a central role, still poorly understood. Here, we focused on the effect of TLR2 ligands in trafficking of T helper cells through reshuffling of CD44 isoforms repertoire. Concurrently, strain background and TLR2 haplotype affected Wnt/β-catenin signaling pathway and expression of splicing factors. During EAE, mCD44 _{v9- v 10} was specifically enriched in the forebrain and showed an increased ability to bind stably to osteopontin. Similarly, we observed that hCD44 _v7 was highly enriched in cells of cerebrospinal fluid from MS patients with active lesions. Moreover, TLRs engagement modulated the composition of C

SUBMITTER: Tredicine M 

PROVIDER: S-EPMC8804271 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature