Surgical Trauma in Mice Modifies the Content of Circulating Extracellular Vesicles.

ABSTRACT: Surgical interventions rapidly trigger a cascade of molecular, cellular, and neural signaling responses that ultimately reach remote organs, including the brain. Using a mouse model of orthopedic surgery, we have previously demonstrated hippocampal metabolic, structural, and functional changes associated with cognitive impairment. However, the nature of the underlying signals responsible for such periphery-to-brain communication remains hitherto elusive. Here we present the first exploratory study that tests the hypothesis of extracellular vesicles (EVs) as potential mediators carrying information from the injured tissue to the distal organs including the brain. The primary goal was to investigate whether the cargo of circulating EVs after surgery can undergo quantitative changes that coul

SUBMITTER: Mkrtchian S 

PROVIDER: S-EPMC8804340 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature