Gene Expression-Based Predication of RNA Pseudouridine Modification in Tumor Microenvironment and Prognosis of Glioma Patients.
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ABSTRACT:
SUBMITTER: Wang LJ
PROVIDER: S-EPMC8804349 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
Gene Expression-Based Predication of RNA Pseudouridine Modification in Tumor Microenvironment and Prognosis of Glioma Patients.
Wang Lin-Jian LJ Lv Peipei P Lou Yongli Y Ye Jianping J
Frontiers in cell and developmental biology 20220118
Aberrant expression of methyltransferases and demethylases may augment tumor initiation, proliferation and metastasis through RNA modification, such as m<sup>6</sup>A and m<sup>5</sup>C. However, activity of pseudouridine (Ψ) modification of RNA remains unknown in glioma, the most common malignant intracranial tumor. In this study, we explored the expression profiles of the Ψ synthase genes in glioma and constructed an efficient prediction model for glioma prognosis based on the CGGA and TCGA da ...[more]
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