DBP rs7041 and DHCR7 rs3829251 are Linked to CD4⁺ Recovery in HIV Patients on Antiretroviral Therapy.

ABSTRACT: Background: The lack of the recovery of CD4⁺ T-cells (CD4⁺ recovery) among immunodeficiency virus (HIV)-infected patients on antiretroviral therapy (ART) is not well known. We aimed to analyze the association between single nucleotide polymorphisms (SNPs) underlying vitamin D metabolism and the CD4⁺ recovery in naïve HIV-infected patients who started ART with low baseline CD4⁺. Methods: We conducted a retrospective study in 411 naïve individuals with plasma HIV load >200 copies/mL and CD4⁺ <200 cells/mm³. During 24 months of follow-up, all patients had plasma HIV load <50 copies/mL. DNA genotyping was performed using the Sequenom MassARRAY platform. The outcome variable was the change in CD4⁺ during

SUBMITTER: Resino S 

PROVIDER: S-EPMC8804497 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature