CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of T_H1 and T_H9 cells.

ABSTRACT:

Background

While stimulator of interferon genes (STING) activation in innate immune cells of the tumor microenvironment can result in CD8 T cell-dependent antitumor immunity, whether STING signaling affects CD4 T-cell responses remains elusive.

Methods

Here, we tested whether STING activation modulated the effector functions of CD4 T cells in vivo by analyzing tumor-infiltrating CD4 T cells and evaluating the contribution of the CD4 T cell-derived cytokines in the antitumor activity of the STING ligand 2'3'-cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) in two mouse tumor models. We performed ex vivo experiments to assess the impact of STING activation on CD4 T-cell differentiation and investigate the underlying molecular mechanisms. Finally, we tested whethe

SUBMITTER: Benoit-Lizon I 

PROVIDER: S-EPMC8804688 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature