Risk factors for herpes zoster in Korean patients with rheumatoid arthritis treated with JAK inhibitor: a nested case-control study.

ABSTRACT:

Objective

To determine the risk of herpes zoster (HZ) in Korean patients with rheumatoid arthritis (RA) receiving Janus kinase inhibitors (JAKis).

Methods

We performed a nested case-control study with 1:10 matching for sex and age using single-centre prospective cohorts of patients with RA receiving targeted therapy in Korea. Then we performed conditional logistic regression analyses to determine the risk associated with JAKi use compared with biologic disease-modifying antirheumatic drug (bDMARD) use, with adjusting for various factors. We also used logistic regression analysis to identify other risk factors for the development of HZ in JAKi users.

Results

From a total of 1147 patients, 61 cases and 610 matched controls were selected. In conditional logistic regressi

SUBMITTER: Song YJ 

PROVIDER: S-EPMC8804703 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature