Tenomodulin and Chondromodulin-1 Are Both Required to Maintain Biomechanical Function and Prevent Intervertebral Disc Degeneration.

ABSTRACT:

Objective

The underlying mechanisms and molecular factors influencing intervertebral disc (IVD) homeostasis and degeneration remain clinically relevant. Tenomodulin (Tnmd) and chondromodulin (Chm1) are antiangiogenic transmembrane glycoproteins, with cleavable C-terminus, expressed by IVD cells that are implicated in the onset of degenerative processes. We evaluate the organ-level biomechanical impact of knocking out Tnmd alone, and Tnmd and Chm1, simultaneously.

Design

Caudal (c5-8) and lumbar vertebrae (L1-4) of skeletally mature male and female 9-month-old wildtype (WT), Tnmd knockout (Tnmd^-/-), and Tnmd/Chm1 double knockout (Tnmd^-/-/Chm^-/-) mice were used (n = 9-13 per group). Disc height index (DHI), histomorphological changes, an

SUBMITTER: Di Pauli von Treuheim T 

PROVIDER: S-EPMC8804743 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature