Collagen Growth Pattern in Human Articular Cartilage of the Knee.

ABSTRACT:

Objective

During skeletal growth, the articular cartilage expands to maintain its cover of bones in joints, however, it is unclear when and how cartilage grows. We aim to determine the expanding growth pattern and timing across the tibia plateau in human knees.

Design

Six human tibia plateaus (2 healthy, 2 with osteoarthritis, and 2 with posttraumatic osteoarthritis) were used for full-depth cartilage sampling systematically across the joint surface at 12 medial and 4 lateral sites. Methodologically, we took advantage of the performed nuclear bomb tests in the years 1955 to 1963, which increased the atmospheric ¹⁴C that was incorporated into human tissues. Cartilage was treated enzymatically to extract collagen, analyzed for ¹⁴C content, and year at for

SUBMITTER: Jorgensen AEM 

PROVIDER: S-EPMC8804751 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature