Effect of Skeletal Paracrine Signals on the Proliferation of Interzone Cells.

ABSTRACT:

Objective

Articular cartilage in mammals has limited intrinsic capacity to repair structural defects, a fact that contributes to the chronic and progressive nature of osteoarthritis. In contrast, Mexican axolotl salamanders have demonstrated the remarkable ability to spontaneously and completely repair large joint cartilage lesions, a healing process that involves interzone cells in the intraarticular space. Furthermore, interzone tissue transplanted into skeletal defects in the axolotl salamander demonstrates a multi-differentiation potential. Cellular and molecular mechanisms of this repair process remain unclear. The objective of this study was to examine whether paracrine mitogenic signals are an important variable in the interaction between interzone cells and the skeletal mic

SUBMITTER: Thampi P 

PROVIDER: S-EPMC8804777 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature