Aging Cartilage in Wild-Type Mice: An Observational Study.

ABSTRACT:

Objective

To describe the spontaneous evolution of age-related changes affecting knee joint articular cartilage, walking speed and a serum biomarker of cartilage remodeling in C57BL/6-JRj wild-type male mice.

Design

Histological changes were assessed by the Osteoarthritis Research Society International (OARSI) score (0=normal, 6=vertical clefts/erosion to the calcified cartilage extending >75% of the articular surface) in newborn, 1-week- and 1-, 3-, 6-, 9- and 12-month-old C57BL/6-JRj wild-type male mice, walking speed by the Locotronic system, and serum C-terminal telopeptide of type II collagen (CTX-II) content by ELISA in 1-, 3-, 6-, and 9-month-old C57BL/6-JRj wild-type male mice.

Results

Mean (SD) OARSI score significantly increased from 0.2 (0.3) to 1.3 (0.6) (

SUBMITTER: Akoum J 

PROVIDER: S-EPMC8804784 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature