Assessment of Native Human Articular Cartilage: A Biomechanical Protocol.

ABSTRACT:

Objectives

Recapitulating the mechanical properties of articular cartilage (AC) is vital to facilitate the clinical translation of cartilage tissue engineering. Prior to evaluation of tissue-engineered constructs, it is fundamental to investigate the biomechanical properties of native AC under sudden, prolonged, and cyclic loads in a practical manner. However, previous studies have typically reported only the response of native AC to one or other of these loading regimes. We therefore developed a streamlined testing protocol to characterize the elastic and viscoelastic properties of human knee AC, generating values for several important parameters from the same sample.

Design

Human AC was harvested from macroscopically normal regions of distal femoral condyles of patients (<

SUBMITTER: Kabir W 

PROVIDER: S-EPMC8804788 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature