Prebiotic and Exercise Do Not Alter Knee Osteoarthritis in a Rat Model of Established Obesity.

ABSTRACT:

Objective

Metabolic disturbance is a known risk factor for cardiovascular disease and has been identified as a risk factor for the development of knee osteoarthritis. In this study, we sought to determine the effects of prebiotic fiber supplementation, aerobic exercise, and the combination of the 2 interventions, on the progression of knee osteoarthritis in a high-fat/high-sucrose diet-induced rat model of metabolic disturbance.

Design

Twelve-week-old male CD-Sprague-Dawley rats were either fed a standard chow diet, or a high-fat/high-sucrose diet. After 12 weeks on diets, rats consuming the high-fat/high-sucrose diet were randomized into 4 subgroups: a sedentary, an aerobic exercise, a prebiotic fiber supplementation, and an aerobic exercise combined with prebiotic fiber su

SUBMITTER: Rios JL 

PROVIDER: S-EPMC8804820 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature