A Synchronized Circadian Clock Enhances Early Chondrogenesis.

ABSTRACT:

Objective

Circadian rhythms in cartilage homeostasis are hypothesized to temporally segregate and synchronize the activities of chondrocytes to different times of the day, and thus may provide an efficient mechanism by which articular cartilage can recover following physical activity. While the circadian clock is clearly involved in chondrocyte homeostasis in health and disease, it is unclear as to what roles it may play during early chondrogenesis.

Design

The purpose of this study was to determine whether the rhythmic expression of the core circadian clock was detectable at the earliest stages of chondrocyte differentiation, and if so, whether a synchronized expression pattern of chondrogenic transcription factors and developing cartilage matrix constituents was present dur

SUBMITTER: Alagha MA 

PROVIDER: S-EPMC8804825 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature