EEG findings in CAR T-cell-associated neurotoxicity: Clinical and radiological correlations.

ABSTRACT:

Background

While EEG is frequently reported as abnormal after chimeric antigen receptor (CAR) T-cell therapy, its clinical significance remains unclear. We aim to systematically describe EEG features in a large single-center cohort and correlate them with clinical and radiological findings.

Methods

We retrospectively identified patients undergoing CAR T-cell therapy who had continuous EEG. Neurotoxicity grades, detailed neurological symptoms, and brain MRI or FDG-PET were obtained. Correlation between clinical and radiological findings and EEG features was assessed.

Results

In 81 patients with median neurotoxicity grade 3 (IQR 2-3), diffuse EEG background slowing was the most common finding and correlated with neurotoxicity severity (P <.001). A total of 42 patients h

SUBMITTER: Beuchat I 

PROVIDER: S-EPMC8804895 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature