Associations of Serum Folate and Vitamin B12 Levels With Cardiovascular Disease Mortality Among Patients With Type 2 Diabetes.

ABSTRACT:

Importance

The associations of serum folate and vitamin B12 levels with cardiovascular outcomes among patients with type 2 diabetes (T2D) remain unclear.

Objective

To investigate the associations of serum folate and vitamin B12 levels with risk of cardiovascular disease (CVD) mortality among individuals with T2D.

Design, setting, and participants

This prospective cohort study included 8067 patients with T2D who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 through 2014 and NHANES III (1988-1994). American Diabetes Association criteria were used to define T2D. Data were analyzed between October 1, 2020, and April 1, 2021.

Exposures

Serum folate and vitamin B12 levels.

Main outcomes and measures

Multivariable Cox p

SUBMITTER: Liu Y 

PROVIDER: S-EPMC8804919 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature