Fecal microbiota transplantation does not alter bacterial translocation and visceral adipose tissue inflammation in individuals with obesity.

ABSTRACT:

Aims

Visceral adipose tissue inflammation is a fundamental mechanism of insulin resistance in obesity and type 2 diabetes. Translocation of intestinal bacteria has been suggested as a driving factor for the inflammation. However, although bacterial DNA was detected in visceral adipose tissue of humans with obesity, it is unclear to what extent this is contamination or whether the gut microbiota is causally involved. Effects of fecal microbiota transplantation (FMT) on bacterial translocation and visceral adipose tissue inflammation in individuals with obesity and insulin resistance were assessed.

Material and methods

Eight individuals with clinically severe obesity (body mass index [BMI] >35 kg/m²) and metabolic syndrome received lean donor FMT 4 weeks prior to el

SUBMITTER: Bakker GJ 

PROVIDER: S-EPMC8804924 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature