Relationship of fasting glucose and longitudinal Alzheimer's disease imaging markers.

ABSTRACT:

Introduction

Fasting glucose increases with age and is linked to modifiable Alzheimer's disease risk factors such as cardiovascular disease and Type 2 diabetes (T2D).

Methods

We leveraged available biospecimens and neuroimaging measures collected during the Alzheimer's Prevention Through Exercise (APEx) trial (n = 105) to examine the longitudinal relationship between change in blood glucose metabolism and change in regional cerebral amyloid deposition and gray and white matter (WM) neurodegeneration in older adults over 1 year of follow-up.

Results

Individuals with improving fasting glucose (n = 61) exhibited less atrophy and regional amyloid accumulation compared to those whose fasting glucose worsened over 1 year (n = 44). Specifically, while individuals with increa

SUBMITTER: Honea RA 

PROVIDER: S-EPMC8804928 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature