Cognitive practice effects delay diagnosis of MCI: Implications for clinical trials.

ABSTRACT:

Introduction

Practice effects (PEs) on cognitive tests obscure decline, thereby delaying detection of mild cognitive impairment (MCI). Importantly, PEs may be present even when there are performance declines, if scores would have been even lower without prior test exposure. We assessed how accounting for PEs using a replacement-participants method impacts incident MCI diagnosis.

Methods

Of 889 baseline cognitively normal (CN) Alzheimer's Disease Neuroimaging Initiative (ADNI) participants, 722 returned 1 year later (mean age = 74.9 ± 6.8 at baseline). The scores of test-naïve demographically matched "replacement" participants who took tests for the first time were compared to returnee scores at follow-up. PEs-calculated as the difference between returnee follow-up scores and

SUBMITTER: Sanderson-Cimino M 

PROVIDER: S-EPMC8804942 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature