Crystal structure of betaine aldehyde dehydrogenase from Burkholderia pseudomallei.

ABSTRACT: Burkholderia pseudomallei infection causes melioidosis, which is often fatal if untreated. There is a need to develop new and more effective treatments for melioidosis. This study reports apo and cofactor-bound crystal structures of the potential drug target betaine aldehyde dehydrogenase (BADH) from B. pseudomallei. A structural comparison identified similarities to BADH from Pseudomonas aeruginosa which is inhibited by the drug disulfiram. This preliminary analysis could facilitate drug-repurposing studies for B. pseudomallei.

SUBMITTER: Beard DK 

PROVIDER: S-EPMC8805214 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature