Blood-Brain Barrier Breakdown in Relationship to Alzheimer and Vascular Disease.

ABSTRACT:

Objective

Blood-brain barrier (BBB) breakdown has been suggested to be an early biomarker in human cognitive impairment. However, the relationship between BBB breakdown and brain pathology, most commonly Alzheimer disease (AD) and vascular disease, is still poorly understood. The present study measured human BBB function in mild cognitive impairment (MCI) patients on 2 molecular scales, specifically BBB's permeability to water and albumin molecules.

Methods

Fifty-five elderly participants were enrolled, including 33 MCI patients and 22 controls. BBB permeability to water was measured with a new magnetic resonance imaging technique, water extraction with phase contrast arterial spin tagging. BBB permeability to albumin was determined using cerebrospinal fluid (CSF)/serum albu

SUBMITTER: Lin Z 

PROVIDER: S-EPMC8805295 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature