SUV39H1 regulates corneal epithelial wound healing via H3K9me3-mediated repression of p27.

ABSTRACT:

Background

Corneal epithelial wound healing (CEWH) is vital for maintaining the integrity and barrier function of the cornea. Although histone modifications mediating gene expression patterns is fundamental in some other tissues, it remains unclear whether these gene regulation patterns underlie CEWH. Suppressor of variegation 3-9 homolog 1 (SUV39H1) plays a vital role in mediating gene silencing via histone H3 trimethylation of lysine 9 (H3K9me3). This study aims to characterize the comprehensive signature of epigenetic modifiers and determine the role of SUV39H1 in CEWH.

Methods

NanoString nCounter technology was used to detect the differentially expressed epigenetic modifiers during CEWH. Bioinformatic analyses were performed to reveal their involvement in this process. A

SUBMITTER: Yang S 

PROVIDER: S-EPMC8805298 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature