YTHDC1 regulates distinct post-integration steps of HIV-1 replication and is important for viral infectivity.

ABSTRACT:

Background

The recent discovery of the role of m⁶A methylation in the regulation of HIV-1 replication unveiled a novel layer of regulation for HIV gene expression. This epitranscriptomic modification of HIV-1 RNAs is under the dynamic control of specific writers and erasers. In addition, cytoplasmic readers of the m⁶A mark are recruited to the modified viral RNAs and regulate HIV-1 replication. Yet, little is known about the effects of m⁶A writers and readers on the biogenesis of HIV-1 RNAs.

Results

We showed that the METTL3/14 m⁶A methyltransferase complex and the m⁶A YTHDF2 cytoplasmic writer down regulates the abundance of HIV-1 RNAs in infected cells. We also identified the m⁶A nuclear writer YTHDC1 as a n

SUBMITTER: N'Da Konan S 

PROVIDER: S-EPMC8805373 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature