Incidence of an Intracellular Multiplication Niche among Acinetobacter baumannii Clinical Isolates.

ABSTRACT: The spread of antibiotic-resistant Acinetobacter baumannii poses a significant threat to public health worldwide. This nosocomial bacterial pathogen can be associated with life-threatening infections, particularly in intensive care units. A. baumannii is mainly described as an extracellular pathogen with restricted survival within cells. This study shows that a subset of A. baumannii clinical isolates extensively multiply within nonphagocytic immortalized and primary cells without the induction of apoptosis and with bacterial clusters visible up to 48 h after infection. This phenotype was observed for the A. baumannii C4 strain associated with high mortality in a hospital outbreak and the A. baumannii ABC141 strain, which was isolated from the skin but was found to be hyperinvasive. Intrac

SUBMITTER: Rubio T 

PROVIDER: S-EPMC8805633 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature