Long-range promoter-enhancer contacts are conserved during evolution and contribute to gene expression robustness.

ABSTRACT: Gene expression is regulated through complex molecular interactions, involving cis-acting elements that can be situated far away from their target genes. Data on long-range contacts between promoters and regulatory elements are rapidly accumulating. However, it remains unclear how these regulatory relationships evolve and how they contribute to the establishment of robust gene expression profiles. Here, we address these questions by comparing genome-wide maps of promoter-centered chromatin contacts in mouse and human. We show that there is significant evolutionary conservation of cis-regulatory landscapes, indicating that selective pressures act to preserve not only regulatory element sequences but also their chromatin contacts with target genes. The extent of evolutionary co

SUBMITTER: Laverre A 

PROVIDER: S-EPMC8805723 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature