⁶⁸Ga-NODAGA-Exendin-4 PET/CT Improves the Detection of Focal Congenital Hyperinsulinism.

ABSTRACT: Surgery with curative intent can be offered to congenital hyperinsulinism (CHI) patients, provided that the lesion is focal. Radiolabeled exendin-4 specifically binds the glucagonlike peptide 1 receptor on pancreatic β-cells. In this study, we compared the performance of ¹⁸F-DOPA PET/CT, the current standard imaging method for CHI, and PET/CT with the new tracer ⁶⁸Ga-NODAGA-exendin-4 in the preoperative detection of focal CHI. Methods: Nineteen CHI patients underwent both ¹⁸F-DOPA PET/CT and ⁶⁸Ga-NODAGA-exendin-4 PET/CT before surgery. The images were evaluated in 3 settings: a standard clinical reading, a masked expert reading, and a joint reading. The target (lesion)-to-nontarget (normal pancreas) ratio was determined using SUV_max</

SUBMITTER: Boss M 

PROVIDER: S-EPMC8805776 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature