Detecting Fibroblast Activation Proteins in Lymphoma Using ⁶⁸Ga-FAPI PET/CT.

ABSTRACT: Cancer-associated fibroblasts that overexpress fibroblast activation protein (FAP) are enriched in many epithelial carcinomas and in hematologic neoplasms. PET/CT with radiolabeled FAP inhibitor (FAPI) is a new diagnostic tool for visualizing the tumor stroma. This prospective study aimed to profile FAPs in different subtypes of lymphomas and explore the potential utility of ⁶⁸Ga-FAPI PET/CT in lymphomas. Methods: In this prospective study, we recruited 73 lymphoma patients who underwent ⁶⁸Ga-FAPI PET/CT and recorded and measured semiquantitative parameters and ratios of their scan results. FAPI expression was assessed by immunochemistry in samples obtained from 22 of the lymphoma patients. Results: We evaluated 11 patients with Hodgkin lymphoma and 62 w

SUBMITTER: Jin X 

PROVIDER: S-EPMC8805784 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature