Molecular diagnosis of Coxiella burnetii in culture negative endocarditis and vascular infection in South Korea.

ABSTRACT:

Background

Q fever endocarditis is a major cause of culture-negative endocarditis. The role of Coxellia burnetii is underestimated because it is difficult to diagnose. We investigated the significance of C. burnetii as the cause of culture-negative endocarditis and vascular infection by examining blood and tissue specimens using serological testing and polymerase chain reaction (PCR).

Methods

All patients with infective endocarditis or large vessel vasculitis were prospectively enrolled at a tertiary-care hospital from May 2016 through September 2020. Q fever endocarditis and vascular infection were diagnosed based on: (1) positive PCR for a cardiac valve or vascular tissue, (2) positive PCR for blood or phase I immunoglobulin G (IgG) ≥ 6400, or (3) phase I IgG

SUBMITTER: Bae M 

PROVIDER: S-EPMC8805875 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature