Obesity and risk of female reproductive conditions: A Mendelian randomisation study.

ABSTRACT:

Background

Obesity is observationally associated with altered risk of many female reproductive conditions. These include polycystic ovary syndrome (PCOS), abnormal uterine bleeding, endometriosis, infertility, and pregnancy-related disorders. However, the roles and mechanisms of obesity in the aetiology of reproductive disorders remain unclear. Thus, we aimed to estimate observational and genetically predicted causal associations between obesity, metabolic hormones, and female reproductive disorders.

Methods and findings

Logistic regression, generalised additive models, and Mendelian randomisation (MR) (2-sample, non-linear, and multivariable) were applied to obesity and reproductive disease data on up to 257,193 women of European ancestry in UK Biobank and publicly availabl

SUBMITTER: Venkatesh SS 

PROVIDER: S-EPMC8806071 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature