Donor-Specific Antibody Is Associated with Increased Expression of Rejection Transcripts in Renal Transplant Biopsies Classified as No Rejection.

ABSTRACT:

Background

Donor -specific HLA antibody (DSA) is present in many kidney transplant patients whose biopsies are classified as no rejection (NR). We explored whether in some NR kidneys DSA has subtle effects not currently being recognized.

Methods

We used microarrays to examine the relationship between standard-of-care DSA and rejection-related transcript increases in 1679 kidney transplant indication biopsies in the INTERCOMEX study (ClinicalTrials.gov NCT01299168), focusing on biopsies classified as NR by automatically assigned archetypal clustering. DSA testing results were available for 835 NR biopsies and were positive in 271 (32%).

Results

DSA positivity in NR biopsies was associated with mildly increased expression of antibody-mediated rejection (ABMR)-related tr

SUBMITTER: Madill-Thomsen KS 

PROVIDER: S-EPMC8806080 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature