Renal Histologic Analysis Provides Complementary Information to Kidney Function Measurement for Patients with Early Diabetic or Hypertensive Disease.

ABSTRACT:

Background

Patients with diabetic or hypertensive kidney disease rarely undergo kidney biopsy because nephrologists commonly believe that biopsy-related risk outweighs the potential benefits of obtaining histologic information to guide clinical decisions. Although kidney function is acutely regulated, histologic changes such as interstitial fibrosis, tubular atrophy, and glomerulosclerosis may represent chronic kidney damage, and thus might provide additional information about disease severity. However, whether histologic analysis provides information complementary to clinically used kidney function measurements, such as eGFR and proteinuria, is unclear.

Methods

We performed a standardized semiquantitative histologic analysis of 859 nephrectomies obtained from individuals wi

SUBMITTER: Quinn GZ 

PROVIDER: S-EPMC8806083 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature