Intermediate Renal Outcomes, Kidney Failure, and Mortality in Obese Kidney Donors.

ABSTRACT:

Background

Obesity is associated with the two archetypal kidney disease risk factors: hypertension and diabetes. Concerns that the effects of diabetes and hypertension in obese kidney donors might be magnified in their remaining kidney have led to the exclusion of many obese candidates from kidney donation.

Methods

We compared mortality, diabetes, hypertension, proteinuria, reduced eGFR and its trajectory, and the development of kidney failure in 8583 kidney donors, according to body mass index (BMI). The study included 6822 individuals with a BMI of <30 kg/m², 1338 with a BMI of 30-34.9 kg/m², and 423 with a BMI of ≥35 kg/m². We used Cox regression models, adjusting for baseline covariates only, and models adjusting for postdonation diabetes

SUBMITTER: Ibrahim HN 

PROVIDER: S-EPMC8806092 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature