Impaired Tubular Secretion of Organic Solutes in Advanced Chronic Kidney Disease.

ABSTRACT:

Background

The clearance of solutes removed by tubular secretion may be altered out of proportion to the GFR in CKD. Recent studies have described considerable variability in the secretory clearance of waste solutes relative to the GFR in patients with CKD.

Methods

To test the hypothesis that secretory clearance relative to GFR is reduced in patients approaching dialysis, we used metabolomic analysis to identify solutes in simultaneous urine and plasma samples from 16 patients with CKD and an eGFR of 7±2 ml/min per 1.73 m² and 16 control participants. Fractional clearances were calculated as the ratios of urine to plasma levels of each solute relative to those of creatinine and urea in patients with CKD and to those of creatinine in controls.

Results

Metabo

SUBMITTER: Mair RD 

PROVIDER: S-EPMC8806100 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature