Differential regulation of cranial and cardiac neural crest by serum response factor and its cofactors.

ABSTRACT: Serum response factor (SRF) is an essential transcription factor that influences many cellular processes including cell proliferation, migration, and differentiation. SRF directly regulates and is required for immediate early gene (IEG) and actin cytoskeleton-related gene expression. SRF coordinates these competing transcription programs through discrete sets of cofactors, the ternary complex factors (TCFs) and myocardin-related transcription factors (MRTFs). The relative contribution of these two programs to in vivo SRF activity and mutant phenotypes is not fully understood. To study how SRF utilizes its cofactors during development, we generated a knock-in Srf^aI allele in mice harboring point mutations that disrupt SRF-MRTF-DNA complex formation but leave SRF-TCF activi

SUBMITTER: Dinsmore CJ 

PROVIDER: S-EPMC8806183 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature