Project description:To date, the majority of authors on scientific publications have been men. While much of this gender bias can be explained by historic sexism and discrimination, there is concern that women may still be disadvantaged by the peer review process if reviewers' biases lead them to reject publications with female authors more often. One potential solution to this perceived gender bias in the reviewing process is for journals to adopt double-blind reviews whereby neither the authors nor the reviewers are aware of each other's identity and gender. To test the efficacy of double-blind reviews in one behavioral ecology journal (Behavioral Ecology, BE), we assigned gender to every authorship of every paper published for 2010-2018 in that journal compared to four other journals with single-blind reviews but similar subject matter and impact factors. While female authorships comprised only 35% of the total in all journals, the double-blind journal (BE) did not have more female authorships than its single-blind counterparts. Interestingly, the incidence of female authorship is higher at behavioral ecology journals (BE and Behavioral Ecology and Sociobiology) than in the ornithology journals (Auk, Condor, Ibis) for papers on all topics as well as those on birds. These analyses suggest that double-blind review does not currently increase the incidence of female authorship in the journals studied here. We conclude, at least for these journals, that double-blind review no longer benefits female authors and we discuss the pros and cons of the double-blind reviewing process based on our findings.
Project description:SignificanceDecision makers now use algorithmic personalization for resource allocation decisions in many domains (e.g., medical treatments, hiring decisions, product recommendations, or dynamic pricing). An inherent risk of personalization is disproportionate targeting of individuals from certain protected groups. Existing solutions that firms use to avoid this bias often do not eliminate the bias and may even exacerbate it. We propose BEAT (bias-eliminating adapted trees) to ensure balanced allocation of resources across individuals-guaranteeing both group and individual fairness-while still leveraging the value of personalization. We validate our method using simulations as well as an online experiment with N = 3,146 participants. BEAT is easy to implement in practice, has desirable scalability properties, and is applicable to many personalization problems.
Project description:Peer review may be "single-blind," in which reviewers are aware of the names and affiliations of paper authors, or "double-blind," in which this information is hidden. Noting that computer science research often appears first or exclusively in peer-reviewed conferences rather than journals, we study these two reviewing models in the context of the 10th Association for Computing Machinery International Conference on Web Search and Data Mining, a highly selective venue (15.6% acceptance rate) in which expert committee members review full-length submissions for acceptance. We present a controlled experiment in which four committee members review each paper. Two of these four reviewers are drawn from a pool of committee members with access to author information; the other two are drawn from a disjoint pool without such access. This information asymmetry persists through the process of bidding for papers, reviewing papers, and entering scores. Reviewers in the single-blind condition typically bid for 22% fewer papers and preferentially bid for papers from top universities and companies. Once papers are allocated to reviewers, single-blind reviewers are significantly more likely than their double-blind counterparts to recommend for acceptance papers from famous authors, top universities, and top companies. The estimated odds multipliers are tangible, at 1.63, 1.58, and 2.10, respectively.
Project description:African Americans are at higher risk of multiple myeloma (MM) yet underrepresented in clinical trials and reap less benefits from novel therapies of the disease. To improve representation of African Americans in MM clinical trials, researchers, providers, patients, industry partners and regulators at the FDA-AACR workshop developed recommendations to all stakeholders. The outlined principles offer a roadmap to addressing disparities broadly in clinical trials.
Project description:Despite the widespread application of point-of-care lateral flow tests, the viscosity dependence of these assay results remains a significant challenge. Here, we employ centrifugal microfluidic flow control through the nitrocellulose membrane of the strip to eliminate the viscosity bias. The key feature is the balancing of the sample flow into the cassette of the lateral flow test with the air flow out of the cassette. A viscosity-independent flow rate of 3.01 ± 0.18 µl/min (±6%) is demonstrated for samples with viscosities ranging from 1.1 mPas to 24 mPas, a factor greater than 20. In a model human IgG lateral flow assay, signal-intensity shifts caused by varying the sample viscosity from 1.1 mPas to 2.3 mPas could be reduced by more than 84%.
Project description:Public health practitioners are often called upon to make inference about a health indicator for a population at large when the sole available information are data gathered from a convenience sample, such as data gathered on visitors to a clinic. These data may be of the highest quality and quite extensive, but the biases inherent in a convenience sample preclude the legitimate use of powerful inferential tools that are usually associated with a random sample. In general, we know nothing about those who do not visit the clinic beyond the fact that they do not visit the clinic. An alternative is to take a random sample of the population. However, we show that this solution would be wasteful if it excluded the use of available information. Hence, we present a simple annealing methodology that combines a relatively small, and presumably far less expensive, random sample with the convenience sample. This allows us to not only take advantage of powerful inferential tools, but also provides more accurate information than that available from just using data from the random sample alone.
Project description:Background/Objectives: To assess the factors affecting the unconscious bias of healthcare professionals (HCPs) in obesity care. Methods: A cross-sectional, non-interventional, descriptive study collecting data via an online survey system was distributed via e-mail to 11,597 members of the Medical Chamber of Slovenia. Physicians were assigned into six HCP categories: (junior) resident physicians, primary care physicians (PCPs), internal medicine specialists, surgeons, dentists, and others. The online questionnaire was active for two weeks. Results: A total of 1248 physicians opened the survey link (10.8% response rate). Of the 898 physicians that engaged in the survey, 789 fully completed the questionnaire. Out of those physicians, 93.6% agreed that obesity is a disease, 83.7% were familiar with the definition, and 75.5% of HCPs were professionally interested in the subject. Overall, 39% of HCPs use the ICD obesity code, primarily primary care physicians and specialists in internal medicine. Notably, 82.0% of HCPs identified lifestyle change as the most effective intervention and believed that patients could lose weight with a serious attempt at a lifestyle change. This belief was particularly supported by male HCPs and HCPs under 40 years of age, who felt that patients were entirely responsible for their weight. The unconscious bias decreased with an increase in the HCPs' body mass index (BMI), but at the same time, physicians with a higher BMI found obesity to be less important than other diseases (p = 0.036). Using composite answers, we found that the unconscious bias of HCPs toward obesity and effective obesity care was significantly related to gender (p = 0.017), age (p < 0.001), and BMI (p = 0.005), and was independent of an area of expertise. Conclusions: HCPs' area of expertise impacted their professional standpoint (suggesting conscious bias), whereas male gender, a younger age, and a lower BMI affected unconscious bias toward obesity and its effective care. Despite their limitations, including the self-reported nature of the data, our findings can help to individualize educational strategies and create a more equitable environment in obesity healthcare.
Project description:BackgroundAttentional bias toward sleep-related information is believed to play a key role in insomnia. If attentional bias is indeed of importance, changing this bias should then in turn have effects on insomnia complaints. In this double-blind placebo controlled randomized trial we investigated the efficacy of attentional bias modification training in the treatment of insomnia.MethodWe administered baseline, post-test, and one-week follow-up measurements of insomnia severity, sleep-related worry, depression, and anxiety. Participants meeting DSM-5 criteria for insomnia were randomized into an attentional bias training group (n = 67) or a placebo training group (n = 70). Both groups received eight training sessions over the course of two weeks. All participants kept a sleep diary for four consecutive weeks (one week before until one week after the training sessions).ResultsThere was no additional benefit for the attentional bias training over the placebo training on sleep-related indices/outcome measures.ConclusionsThe absence of the effect may be explained by the fact that there was neither attentional bias at baseline nor any reduction in the bias after the training. Either way, this study gives no support for attentional bias modification training as a stand-alone intervention for ameliorating insomnia complaints.
Project description:BackgroundUnconscious or implicit biases are universal and detrimental to health care and the learning environment but can be corrected. Historical interventions used the Implicit Association Test (IAT), which may have limitations.ObjectiveWe determined the efficacy of an implicit bias training without using the IAT.MethodsFrom April 2019 to June 2020, a 90-minute educational workshop was attended by students, residents, and faculty. The curriculum included an interactive unconscious biases presentation, videoclips using vignettes to demonstrate workplace impact of unconscious biases with strategies to counter, and reflective group discussions. The evaluation included pre- and postintervention surveys. Participants were shown images of 5 individuals and recorded first impressions regarding trustworthiness and presumed profession to unmask implicit bias.ResultsOf approximately 273 participants, 181 were given the survey, of which 103 (57%) completed it with significant increases from pre- to postintervention assessments for perception scores (28.87 [SEM 0.585] vs 32.73 [0.576], P < .001) and knowledge scores (5.68 [0.191] vs 7.22 [0.157], P < .001). For a White male physician covered in tattoos, only 2% correctly identified him as a physician, and 60% felt he was untrustworthy. For a smiling Black female astronaut, only 13% correctly identified her as an astronaut. For a brooding White male serial killer, 50% found him trustworthy.ConclusionsAn interactive unconscious bias workshop, performed without the use of an IAT, was associated with increases in perceptions and knowledge regarding implicit biases. The findings also confirmed inaccurate first impression stereotypical assumptions based on ethnicity, outward appearances, couture, and media influences.
Project description:The relative contributions of transmission and reactivation of latent infection to TB cases observed clinically has been reported in many situations, but always with some uncertainty. Genotyped data from TB organisms obtained from patients have been used as the basis for heuristic distinctions between circulating (clustered strains) and reactivated infections (unclustered strains). Naïve methods previously applied to the analysis of such data are known to provide biased estimates of the proportion of unclustered cases. The hypergeometric distribution, which generates probabilities of observing clusters of a given size as realized clusters of all possible sizes, is analyzed in this paper to yield a formal estimator for genotype cluster sizes. Subtle aspects of numerical stability, bias, and variance are explored. This formal estimator is seen to be stable with respect to the epidemiologically interesting properties of the cluster size distribution (the number of clusters and the number of singletons) though it does not yield satisfactory estimates of the number of clusters of larger sizes. The problem that even complete coverage of genotyping, in a practical sampling frame, will only provide a partial view of the actual transmission network remains to be explored.