The association between hypertension and nonalcoholic fatty liver disease (NAFLD): literature evidence and systems biology analysis.

ABSTRACT: Nonalcoholic fatty liver disease (NAFLD) has become a major public health issue as its progression increases risks of multisystem morbidity and mortality. Recent evidence indicates a more complex relationship between hypertension and NAFLD than previously thought. In this study, a comprehensive literature search was used to gather information supporting the comorbidity phenomenon of hypertension and NAFLD. Then, systems biology approach was applied to identify the potential genes and mechanisms simultaneously associated with hypertension and NAFLD. With the help of protein-protein interaction network-based algorithm, we found that the distance between hypertension and NAFLD was much less than random ones. Sixty-four shared genes of hypertension and NAFLD modules were identified as core gen

SUBMITTER: Ma C 

PROVIDER: S-EPMC8806441 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature