Gene expression and prognosis of x-ray repair cross-complementing family members in non-small cell lung cancer.

ABSTRACT: The X-ray repair cross-complementing gene (XRCC) family participates in DNA damage repair and its dysregulation is associated with the development and progression of a variety of cancers. However, XRCCs have not been systematically studied in non-small cell lung cancer (NSCLC). Using The Cancer Genome Atlas (TCGA) and Oncomine databases, we compared the expression levels of XRCCs between NSCLC and normal tissues and performed survival analysis using the data from TCGA. The correlations of XRCCs with the clinical parameters were then analyzed using UCSC Xena. Genetic alterations in XRCCs in NSCLC and their effects on the prognosis of patients were presented using cBioPortal. SurvivalMeth was used to explore the differentially methylated sites associated wi

SUBMITTER: Fan Y 

PROVIDER: S-EPMC8806547 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature