Uncovering antiobesity-related hypertension targets and mechanisms of metformin, an antidiabetic medication.

ABSTRACT: Metformin, a common clinical drug used to treat diabetes mellitus, is found with potential antiobese actions as reported in increasing evidences. However, the detailed mechanisms of metformin-antiobesity-related hypertension remain unrevealed. We have utilized the bioinformatics strategy, including network pharmacology and molecular docking analyses, to uncover pharmacological targets and molecular pathways of bioactive compounds against clinical disorders, such as cancers, coronavirus disease 2019. In this report, the in-silico approaches using network pharmacology and molecular docking was utilized to identify the core targets, pharmacological functions and mechanisms of metformin against obesity-related hypertension. The networking analysis identified 154 differentially expressed

SUBMITTER: Yang L 

PROVIDER: S-EPMC8806643 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature