A pan-cancer analysis of the prognostic and immunological role of β-actin (ACTB) in human cancers.

ABSTRACT: Beta-actin (ACTB), a highly conserved cytoskeleton structural protein, has been regarded as a common housekeep gene and used as a reference gene for years. However, accumulating evidence indicates that ACTB is abnormally expressed in multiple cancers and hence changes the cytoskeleton to affect the invasiveness and metastasis of tumors. This study aimed to investigate the function and clinical significance of ACTB in pan-cancer. The role of ACTB for prognosis and immune regulation across 33 tumors was explored based on the datasets of gene expression omnibus and the cancer genome atlas. Differential expression of ACTB was found between cancer and adjacent normal tissues, and significant associations was found between ACTB expression and prognosis of tumor patients. In most cancers, ACTB ex

SUBMITTER: Gu Y 

PROVIDER: S-EPMC8806805 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature