Sonication strategies toward volumetric ultrasound hyperthermia treatment using the ExAblate body MRgFUS system.

ABSTRACT:

Purpose

The ExAblate body MRgFUS system requires advanced beamforming strategies for volumetric hyperthermia. This study aims to develop and evaluate electronic beam steering, multi-focal patterns, and sector vortex beamforming approaches in conjunction with partial array activation using an acoustic and biothermal simulation framework along with phantom experiments.

Methods

The simulation framework was developed to calculate the 3D acoustic intensity and temperature distribution resulting from various beamforming and scanning strategies. A treatment cell electronically sweeping a single focus was implemented and evaluated in phantom experiments. The acoustic and thermal focal size of vortex beam propagation was quantified according to the vortex modes, number of active arra

SUBMITTER: Kim K 

PROVIDER: S-EPMC8806831 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature