Identification of circRNA_001846 as putative non-small cell lung cancer biomarker.

ABSTRACT: CircRNAs play diverse roles in the regulation of oncogenic processes, yet the roles of these circRNAs in non-small cell lung cancer (NSCLC) remain to be fully clarified. Herein, patterns of circRNA expression in NSCLC tissues and paracancerous tissues were assessed, and the relationships between these circRNAs and NSCLC patient clinical findings were assessed. NSCLC tissues were evaluated using a circRNA microarray approach, with Quantitative real‑time polymerase chain reaction (qPCR) qPCR being used to validate candidate circRNA expression levels in NSCLC patients peripheral blood samples. GEO2R was used to analyze the array data. SPSS23.0, GraphPad Prism, and Sigmaplot were utilized for statistical analyses. Overall, 114 circRNAs that were differentially expressed in NSCLC tissue relativ

SUBMITTER: Yang F 

PROVIDER: S-EPMC8806949 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature