Long-Term Blood Pressure Variability and Kidney Function in Participants of the ASPREE Trial.

ABSTRACT:

Background

Whether long-term blood pressure variability (BPV) predicts kidney function decline in generally healthy older adults is unknown. We investigated this association in ASPirin in Reducing Events in the Elderly (ASPREE) trial participants.

Methods

Between 2010 and 2014, Australian and US individuals aged ≥70 years (≥65 if US minority) were recruited and followed with annual study visits for a median of 4.7 years. Time-to-event analyses and linear mixed effects models were used to examine associations between incident chronic kidney disease (CKD), and trajectories of estimated glomerular filtration rate (eGFR) and log albumin-creatinine ratio (log ACR) with systolic BPV as a continuous measure, and, by tertile of SD of systolic blood pressure (BP). BPV was estimated u

SUBMITTER: Ernst ME 

PROVIDER: S-EPMC8807162 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature