Computational characterization of domain-segregated 3D chromatin structure and segmented DNA methylation status in carcinogenesis.

ABSTRACT: The high-order chromatin structure, together with DNA methylation and other epigenetic marks, plays a vital role in gene regulation and displays abnormal status in cancer cells. Theoretical analyses are expected to provide a more unified understanding of the multi-omics data on the large variety of samples, and hopefully a common picture of carcinogenesis. In particular, we are interested in the question of whether an underlying origin DNA sequence exists for these epigenetic alterations. The human genome consists of two types of megabase-sized domain based on the distribution of CpG islands (CGIs) that show distinct structural, epigenetic, and transcriptional properties: CGI-rich and CGI-poor domains. Through an integrated analysis of chromatin structure, DNA methylation, and RNA sequenci

SUBMITTER: Xue Y 

PROVIDER: S-EPMC8807360 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature