The pleiotropic roles of circular and long noncoding RNAs in cutaneous melanoma.

ABSTRACT: Cutaneous melanoma (CM) is a very aggressive disease, often characterized by unresponsiveness to conventional therapies and high mortality rates worldwide. The identification of the activating BRAF^V600 mutations in approximately 50% of CM patients has recently fueled the development of novel small-molecule inhibitors that specifically target BRAF^V600 -mutant CM. In addition, a major progress in CM treatment has been made by monoclonal antibodies that regulate the immune checkpoint inhibitors. However, although target-based therapies and immunotherapeutic strategies have yielded promising results, CM treatment remains a major challenge. In the last decade, accumulating evidence points to the aberrant expression of different types of noncoding RNAs (ncRNAs) in CM. While

SUBMITTER: Montico B 

PROVIDER: S-EPMC8807361 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature