Ontology highlight
ABSTRACT:
SUBMITTER: Cappelli LV
PROVIDER: S-EPMC8807394 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Cappelli Luca Vincenzo LV Meggendorfer Manja M Baer Constance C Nadarajah Niroshan N Hutter Stephan S Jeromin Sabine S Dicker Frank F Kern Wolfgang W Haferlach Torsten T Haferlach Claudia C Höllein Alexander A
Leukemia 20210810 2
In AML patients, recurrent mutations were shown to persist in remission, however, only some have a prognostic value and persistent mutations might therefore reflect a re-established premalignant state or truly active disease causing relapse. We aimed to dissect the nature of co-mutations in NPM1 mutated AML where the detection of NPM1 transcripts allows highly specific and sensitive detection of complete molecular remission (CMR). We analysed 150 consecutive patients who achieved CMR following i ...[more]